How Progesterone Affects Brain Health
Progesterone is often thought of in relation to reproductive health, but its influence extends far beyond the ovaries. This crucial hormone plays a significant role in brain health and function, affecting everything from mood to cognitive performance. As women enter perimenopause and menopause, declining progesterone levels can lead to a range of symptoms that impact both mental and emotional well-being.
The Changing Of Progesterone Levels Over Time
During a woman’s reproductive years, progesterone helps maintain a balance with estrogen, supporting a healthy menstrual cycle and pregnancy. However, as women enter perimenopause, typically in their 40s, these levels begin to fluctuate and decline. This hormonal imbalance can lead to various symptoms, including mood swings, anxiety, and even depression. Women may find themselves feeling more irritable or emotionally fragile, often wondering if they are simply stressed or experiencing something more profound. We hear from many women that they “just don’t feel like themselves.” Interestingly enough, this feeling (dubbed NFLM) has actually been studied, and if you are also feeling like this, you are definitely not alone.
How Progesterone Affects The Brain
Did you know that the brain actually has progesterone receptors? What’s more, the number and distribution suggest that neural activity is heavily influenced by the presence of progesterone. It has been shown to help re-coat the nerve cells in the brain, to allow for transmission of neural signals. Studies also show that it has a calming effect, as it stimulates GABA receptors (the feel good, calming neurotransmitter). In addition, progesterone helps to regulate mood and supports cognition. Many women are somewhat familiar with the hijacking of their mood during their cycle, and the changes during perimenopause can be even more pronounced. Some women even report difficulty concentrating, memory lapses, and a general sense of “brain fog.” This goes beyond just nuisance. It can significantly affect daily life and productivity.
Hormone Replacement Therapy Can Help
Fortunately, many of these symptoms can be alleviated with hormone replacement therapy (HRT). By reintroducing progesterone into the body, HRT can help restore hormonal balance and alleviate the emotional and cognitive symptoms associated with its decline. Studies have shown that HRT can improve mood, reduce anxiety, and enhance cognitive function in women experiencing perimenopause and menopause-related symptoms. To discuss HRT and find out if you might be a good candidate for treatment, schedule an appointment with us. We will go through your health history and current symptoms, and help you decide if HRT is right for you.